Stratum Corneum Evaluation by Tape Stripping
Acceleration of quantitative measurement
Skin condition can be evaluated by collecting corneocytes from the skin using the tape stripping technique and measuring the area of each cell and the ratio of stratified cells under a microscope. This evaluation can assess how much the skin turnover*1 has improved due to the use of cosmetic products. However, these measurements were time-consuming with conventional methods, so it was incredibly difficult to improve reliability by increasing the number of specimens for analysis.
- Using the All-in-One Fluorescence Microscope BZ-X800
Skin cells are developed in the basal cell layer, which is the bottommost layer in the epidermis, and are eventually pushed upward and become “horny cells” (corneocytes). Dead skin cells peel off over time. If this cycle, called the turnover, is normal, the area and stratification of corneocytes are uniform. However, when turnover becomes irregular due to skin damage, the formation of immature cells and the unwanted retention of the stratum corneum lead to the skin losing its moisturizing function and barrier function, possibly resulting in skin irritation, blemishes, and other skin problems.