Micronucleus Test*1
Image stitching & quantification
The micronucleus test evaluates the presence of micronuclei and is used as a genetic toxicology test for identifying chromosomal aberrations. It is commonly conducted through visual observation using a microscope. However, to obtain statistically significant data, a substantial number of cells must be observed. Finding micronuclei—each only around 1 µm in diameter—from an enormous number of cells is a burdensome and time-consuming task for the testing staff.
Image stitching and quantification can also be used when performing a comet assay, another genetic toxicology test.
- Using the All-in-One Fluorescence Microscope BZ-X800
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- The image stitching function allows you to automatically capture images with both high resolution and wide field of view.
The testing staff only needs to find micronuclei by looking at the captured images on the monitor, a simplification that significantly reduces their work load. - The Hybrid Cell Count can be used to extract micronuclei by setting the masked measurement function and size specification. These settings can drastically shorten the time required to obtain test results.
- The high-sensitivity, cooled CCD monochrome camera, which is optimal for fluorescence microscopy, can be switched to color observation mode for optimal brightfield observation at the push of a button, supporting a variety of microscopic tests.
- The image stitching function allows you to automatically capture images with both high resolution and wide field of view.
*1 Micronucleus test:
A micronucleus is a small nucleus that forms separately from the normal nucleus in a cell when a fragment of a chromosome damaged by chemical substances or ultraviolet rays is not incorporated into and remains outside the daughter nuclei during cell division. The micronucleus test evaluates the presence of micronuclei and is used as a genetic toxicology test for identifying chromosomal aberrations.
- Here are some examples of using the All-in-One Fluorescence Microscope BZ-X800 in front-line research.
- [Regenerative Medicine] BZ Series Provides Essential Imaging for Neural Stem Cell and Spinal Observation
- [Gene Therapy] Improving Research for the Development of Gene Therapy Drugs
- [Heart Disease Treatment] Developing Cell Sheets for Myocardial Regenerative Treatments
- [Cancer Treatment] Automated Fluorescence Microscope Transforms Process for Induced Cancer Stem Cell Research
- [Immune System] BZ Series Contributes to Understanding the Pathological Model of Asthma
- [Biomaterials] Promoting Efficiency in Research With Compact, User-friendly Microscopes