Fluorescence Microscopes
Efficient All-in-One Fluorescence Microscope Supports RNA Nanocarrier Development Shengdi Biotech: A Pioneer in Nanodelivery Technology
Learn how Shengdi Bio enhances R&D efficiency and drives innovation with KEYENCE's BZ-X fluorescence microscope.
Shengdi Biotech: Advancing RNA Therapy Through Nanodelivery
NeoLNP™ Series Transfection Reagent Kits
In biomedicine, technological breakthroughs rely on high-precision experimental equipment. Shengdi Biopharmaceutical (Suzhou) Co., Ltd. (“Shengdi Bio”), a leading nanocarrier R&D company in China, has achieved remarkable progress in RNA therapy and nanodelivery technologies. KEYENCE’s All-in-One fluorescence microscopy system, the BZ-X, provides crucial support for Shengdi Bio’s research, enhancing both efficiency and accuracy.
Chen Xiaobao, General Manager of Shengdi Biotech (left), and Takuya Ichimura, Head of KEYENCE's Fluorescence Microscope Division (right)
Founded in 2021 and headquartered in Suzhou Industrial Park BioBAY, Shengdi Biotech is an R&D platform focused on independent innovation in nanocarrier technology. The company promotes basic research and clinical translation of cutting-edge synthetic biology technologies such as RNA therapy through advanced nanodelivery systems.
Cellular and humoral immune responses induced by messenger RNA (mRNA) vaccine.
Fang, E., Liu, X., Li, M. et al. Advances in COVID-19 mRNA vaccine development.
Sig Transduct Target Ther 7, 94 (2022).
Shengdi Bio has successfully developed the i-Core LNP™, an extrahepatic targeted RNA delivery system that includes innovative administration methods such as lung inhalation and local skin delivery. The company has also made significant advancements in delivering lipid nanoparticles (LNPs) to immune and stem cells.
NeoLNP™ Technology: An Innovative Practice for Efficiently Encapsulating RNA in 1 Minute
* Conventional LNP Preparation
Shengdi Biotech LNP Preparation
At the core of Shengdi Bio’s platform is the NeoLNP™ series, based on proprietary LNP technology. NeoLNP™ efficiently encapsulates RNA and delivers it via a unique transmembrane transport and endosomal escape mechanism. This technology is suitable for RNA transfection in both cells and animals and supports applications including RNA therapy, gene editing, and vaccine research.
NeoLNP™ Technology: Rapid and Efficient RNA Encapsulation
NeoLNP™ technology exemplifies Shengdi Bio’s R&D achievements. It enables RNA encapsulation in under one minute without specialized equipment, is easy to operate, and significantly improves experimental efficiency. Through LNP-mediated transmembrane transport and endosomal escape, NeoLNP™ ensures efficient RNA release in cells, unlocking its gene regulatory potential.
The NeoLNP™ series includes products for general-purpose, immunocellular, and in vivo transfection, supporting various RNA types such as mRNA, siRNA, and circRNA. From cell culture to animal experiments, NeoLNP™ provides efficient, stable transfection with minimal cytotoxicity, ensuring reliable and safe results.
KEYENCE BZ-X: Accelerating R&D Efficiency
During NeoLNP™ RNA kit development, KEYENCE’s BZ-X All-in-One fluorescence microscope has been instrumental in improving both experimental efficiency and data accuracy.
R&D Process Flowchart for mRNA-LNP (using a vaccine as an example)
Using the separation function to count adjacent cells individually
Automatic Continuous Imaging and Cell Counting: The BZ-X can capture dozens or even hundreds of samples in one session and quickly analyze fluorescent cell proportions using built-in software. This automation simplifies workflows, saves significant time, and accelerates R&D progress.
Improved Accuracy and Consistency: Previously, Shengdi Bio relied on manual imaging, capturing cells one sample at a time. The BZ-X ensures consistent data across experiments, enabling faster development and reliable results.
Versatile and User-Friendly: Supporting fluorescence, brightfield, and phase contrast imaging, the BZ-X is suitable for cell counting, live-cell imaging, 3D measurement, and more. Its intuitive interface allows researchers, to operate the system efficiently.
Reliable Support and Service
KEYENCE provides responsive technical support, on-site demonstrations, and detailed operational guidance, helping Shengdi Bio researchers quickly master the system. This service ensures smooth integration into R&D workflows, which is crucial for companies pursuing high-quality, efficient research.
All of the above are fluorescence images of various transfected cells captured with the BZ-X
Key Features of KEYENCE BZ-X
KEYENCE's BZ-X All-in-One Fluorescence Microscope has become the ideal choice for many biopharmaceutical companies due to its excellent performance and convenient operation. Here are some of the major advantages of the BZ-X:
All-in-One Fluorescence Microscope BZ-X
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1High-Sensitivity Imaging: Equipped with a black-and-white refrigerated CCD camera and high-brightness, long-life LED light source for precise fluorescence detection.
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2Automatic Multi-Sample Analysis: Captures multiple samples simultaneously and analyzes fluorescent cell proportions efficiently.
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3Easy Operation with Rich Functionality: Intuitive interface reduces training time, supporting diverse observation methods for a variety of applications.
For companies involved in RNA therapy, gene editing, or vaccine development, the KEYENCE BZ-X fluorescence microscope is a reliable tool that enhances experimental efficiency, ensures accurate results, and supports advanced R&D initiatives.
A KEYENCE engineer providing operational guidance
Convenient Operation and After-Sales Service
The BZ-X features a user-friendly interface that reduces training time for experimenters, allowing them to quickly learn and operate the system. KEYENCE’s technical support team responds promptly, providing detailed operational guidance during initial use and conducting on-site demonstrations and explanations as needed. This strong, hands-on support enables Shengdi Bio’s R&D personnel to quickly master the equipment and is particularly valuable for companies aiming to maximize R&D efficiency.
